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U's finish their home campaign in style
Ian Henderson headed the U's ahead after three minutes from Brian Wilson's cross.
Anthony Wordsworth came close to making it 2-0 soon after and Henderson clipped the bar with another header, as Colchester started the game well.
The U's went further ahead early in the second half through Tom Eastman's far post header from the impressive Lloyd James' pass.
James Wallace pulled a goal back with a long-range low effort soon after, before Ian Goodison's own goal restored Colchester's two-goal advantage.
Lucas Akins' effort deflected in off Jake Cassidy for Tranmere's second goal to give them hope but a fine solo effort by substitute Freddie Sears sealed a fine win for the U's and ended their run of 11 matches without a win in League One.
For a full match report, pictures and reaction from Colchester United's game with Tranmere Rovers, see Monday's Gazette.